Super Falcons fell 2-0 in the first of the two Friendly matches to be played with world champions Japan.
The Falcons held the world champions until late in the second half when Yuki Ogimi scored the first goal. Isihaya made it 2-0 in the 67th minute.
Sasaki Norio called up a total of 41 players for the encounter and he hopes it would be an opportunity to assess the players he would be using when Japan gets its campaign underway at the Asian Cup.
Both sides will meet again on Thursday at the Fukuda Denshi Arena in Japan.